Invention Grant
- Patent Title: Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
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Application No.: US16267615Application Date: 2019-02-05
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Publication No.: US11052103B2Publication Date: 2021-07-06
- Inventor: Kevin Fitzgerald , Gregory Hinkle
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Laceotripe Zacharakis; Deborah L. Nagle
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/02 ; A61K31/7125 ; C12P19/34 ; C12Q1/68 ; C07H19/067 ; C07H19/167
Abstract:
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene, and methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and methods of treating subjects having Nonalcoholic Fatty Liver Disease (NAFLD) and/or a PNPLA3-associated disorder.
Public/Granted literature
- US20190216845A1 PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Public/Granted day:2019-07-18
Information query
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