Invention Grant
- Patent Title: Method of committed differentiation of human induced pluripotent stem cells into Leydig cells and application of Leydig cells
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Application No.: US15987953Application Date: 2018-05-24
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Publication No.: US11052120B2Publication Date: 2021-07-06
- Inventor: Peng Xiang , Mei Hua Jiang , Weiqiang Li
- Applicant: SUN YAT-SEN UNIVERSITY
- Applicant Address: CN Guangdong
- Assignee: SUN YAT-SEN UNIVERSITY
- Current Assignee: SUN YAT-SEN UNIVERSITY
- Current Assignee Address: CN Guangdong
- Agency: Metis IP LLC
- Priority: CN201510845021.8 20151127
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; A61K35/52 ; C12N5/071 ; A61K45/00 ; A61P5/26 ; C12N5/0735 ; A61K38/18
Abstract:
The present application provides an in-vitro committed differentiation method for inducing human induced pluripotent stem cells (hiPSCs) into Leydig cells (LCs) by neural crest stem cells (NCSCs). The hiPS-derived LCs is verified by an animal model to have the capacity of regenerating senile or injured LCs, so that a new treatment for supplementing testosterone is provided for patients suffering from hypogonadism, particularly for patients suffering from late-onset hypogonadism (LOH).
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