An oxygen delivery system provides controlled flow of oxygen-enriched gas to a patient. The system includes one or more sensors configured to measure respiration rate information and heart rate information of the patient. A computer system including one or more physical processors is operatively connected with the sensors. The physical processors are programmed with computer program instructions which, when executed cause the computer system to determine a metabolic oxygen consumption information of the patient from the respiration rate information and the heart rate information from the one or more sensors, and continuously adjust flow, volume and/or pressure of the oxygen-enriched gas delivered from an oxygen source of the oxygen delivery system to the patient based on the determined metabolic oxygen consumption information of the patient.