Invention Grant
- Patent Title: Polymorphic forms of kinase inhibitor compound, pharmaceutical composition containing same, preparation method therefor and use thereof
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Application No.: US16338357Application Date: 2017-09-29
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Publication No.: US11053224B2Publication Date: 2021-07-06
- Inventor: Congxin Liang , Lihua Xie
- Applicant: EQUINOX SCIENCES, LLC
- Applicant Address: US DE Wilmington
- Assignee: EQUINOX SCIENCES, LLC
- Current Assignee: EQUINOX SCIENCES, LLC
- Current Assignee Address: US DE Wilmington
- Agency: Novick, Kim & Lee, PPLC
- Agent Allen Xue
- Priority: CN201610866253.6 20160929
- International Application: PCT/CN2017/104506 WO 20170929
- International Announcement: WO2018/059556 WO 20180405
- Main IPC: C07D403/14
- IPC: C07D403/14 ; A61K9/48 ; A61K9/20 ; A61P35/00 ; A61K31/404

Abstract:
The invention discloses polymorphic forms of a compound of formula I, pharmaceutical compositions containing same, preparation method therefor and use thereof. The compound of formula I of the present invention is as shown in formula I, of which the crystalline form can be crystalline form 1, crystalline form 2, crystalline form 3, crystalline form 5, crystalline form 6 or crystalline form 7. All the crystalline forms of the compound of formula I in the present invention have good crystalline stability and chemical stability and a decrease in purity of their main ingredient less than 2%. The preparation method of the present invention may be used to produce the various crystalline forms of the compound of formula I with high purity, and suitable for large scale production.
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