Invention Grant
- Patent Title: Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates
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Application No.: US16954704Application Date: 2018-12-19
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Publication No.: US11053227B2Publication Date: 2021-07-06
- Inventor: Corrado Colli , Giorgio Bertolini , Mara Sada , Faris Garis , Filippo Nisic , Aldo Bianchi , Cinzia Biaggi , Romano Di Fabio , Silvano Ronzoni , Stefania Bertuolo , Adolfo Prandi , Stefano Maiorana
- Applicant: OLON S.P.A.
- Applicant Address: IT Rodano
- Assignee: OLON S.P.A.
- Current Assignee: OLON S.P.A.
- Current Assignee Address: IT Rodano
- Agent Silvia Salvadori
- Priority: IT102017000147611 20171220
- International Application: PCT/IB2018/060335 WO 20181219
- International Announcement: WO2019/123311 WO 20190627
- Main IPC: C07D405/06
- IPC: C07D405/06 ; C07D207/408 ; C12P13/02
Abstract:
Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
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