Invention Grant
![[9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto](/docs/US/2021-07-06/US11053242B2/abs.jpg.600x600.jpg)
- Patent Title: [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
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Application No.: US16748999Application Date: 2020-01-22
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Publication No.: US11053242B2Publication Date: 2021-07-06
- Inventor: Neil Ashweek , Nicole Harriott
- Applicant: Neurocrine Biosciences, Inc.
- Applicant Address: US CA San Diego
- Assignee: Neurocrine Biosciences, Inc.
- Current Assignee: Neurocrine Biosciences, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Fish & Richardson P.C.
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D455/04 ; C07D519/00
![[9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto](/abs-image/US/2021/07/06/US11053242B2/abs.jpg.150x150.jpg)
Abstract:
Compounds having a structure of formula (I), including stereoisomers and pharmaceutically acceptable salts and solvates thereof: wherein R1 is as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (VMAT2) and have utility for treating, for example, hyperkinetic disorders. Also disclosed are compositions containing these compounds in combination with a pharmaceutically acceptable carrier or diluent, as well as methods relating to the use in a subject in need thereof.
Public/Granted literature
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