Invention Grant
- Patent Title: Crystal of cephalosporin intermediate 7α-methoxy cephalothin and method for preparing same
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Application No.: US16494276Application Date: 2018-02-23
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Publication No.: US11053259B2Publication Date: 2021-07-06
- Inventor: Chuanshan Hou , Fei Tang , Meiju Fan , Xin Wang , Jinglong Fu , Michao Shi , Xi Lei , Hongmei Xu
- Applicant: QILU ANTIBIOTICS PHARMACEUTICAL CO. LTD.
- Applicant Address: CN Jinan
- Assignee: QILU ANTIBIOTICS PHARMACEUTICAL CO. LTD.
- Current Assignee: QILU ANTIBIOTICS PHARMACEUTICAL CO. LTD.
- Current Assignee Address: CN Jinan
- Agency: CBM Patent Consulting, LLC
- Priority: CN201710214602.0 20170401
- International Application: PCT/CN2018/077000 WO 20180223
- International Announcement: WO2018/177048 WO 20181004
- Main IPC: C07D501/34
- IPC: C07D501/34

Abstract:
The present invention relates to a crystal of cephalosporin intermediate 7α-methoxy cephalothin (I) and a method for preparing same. The crystal of 7α-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2θ; the crystal of 7α-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.34°±0.20°, 12.71°±0.20°, 14.25°±0.20°, 14.68°±0.20°, 16.52°±0.20°, 17.99°±0.20°, 19.98°±0.20°, and 22.69°±0.20°. The crystal of 7α-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7α-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7α-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.
Information query
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