Invention Grant
- Patent Title: Method for preparation of dried blood sample for multiplexing of analytes
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Application No.: US16861554Application Date: 2020-04-29
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Publication No.: US11054349B2Publication Date: 2021-07-06
- Inventor: David J. Smith , Matthew D. Rifat , Christian Tagwerker , Irfan Baig , Ranulu Samanthi de Zoysa , Eric J. Brunson
- Applicant: Alcala Pharmaceutical, Inc.
- Applicant Address: US CA San Diego
- Assignee: Alcala Pharmaceutical, Inc.
- Current Assignee: Alcala Pharmaceutical, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Roeder & Broder LLP
- Agent James P. Broder
- Main IPC: A61L2/10
- IPC: A61L2/10 ; G01N1/38 ; G01N30/06 ; G01N30/72

Abstract:
A method for preparation of a dried blood sample for multiplexing of analytes includes the steps of mixing an Internal Standard solution with a first diluent in a vessel, the Internal Standard solution including a plurality of different Internal Standards, adding the dried blood sample to the vessel, sonicating the vessel containing the Internal Standard solution, the first diluent and the dried blood sample, and removing the dried blood sample from the vessel. The Internal Standard solution can include a plurality of Internal Standards. The Internal Standard solution can include at least 15 Internal Standards. The dried blood sample can be generated using less than 50 μL of blood. The dried blood sample can be generated using less than 10 μL of blood. The first diluent can include methanol or a mixture of water and methanol.
Public/Granted literature
- US20200256772A1 METHOD FOR QUALITATIVE AND QUANTITATIVE MULTIPLEXING OF DRUG ANALYTES FROM BIOLOGICAL SAMPLES Public/Granted day:2020-08-13
Information query
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