Embodiments of this application disclose an interference cancellation method and a base station. The method in the embodiments of this application may include obtaining, by a first base station, system information of a neighboring cell. The method may also include determining, by the first base station, interference channel information of a second base station to the first base station based on the system information, where the second base station is a base station in a coverage area of the neighboring cell. Furthermore, the method may also include receiving, by the first base station based on the interference channel information, an uplink signal sent by user equipment in a coverage area of the first base station.