A Network Function Virtualization (NFV) system implements hardware trusted Management and Orchestration (MANO). A Hardware (HW) trust server issues a HW trust challenge to a first MANO system. The first MANO system hashes its physically-embedded read-only hardware trust key to generate a HW trust result and transfers the HW trust result to the HW trust server. The HW trust server validates the hardware trust result and transfers a HW trust certificate to the first MANO system. The first MANO system transfers the HW trust certificate and NFV MANO data to a second MANO system. The second MANO system validates the HW trust certificate. The second MANO system exchanges NFVI control data with NFVI circuitry responsive to the NFV MANO data when the HW trust certificate is valid. The second MANO system isolates the NFV MANO data when the HW trust certificate is not valid.