Provided are computer-implemented methods and systems for optimization of publication of an application to a web browser. An example method for optimization of publication of an application to a web browser may include capturing, by a server-side agent, a video frame of a virtual screen associated with the application. The method may further include comparing, by the server-side agent, the video frame to a previous video frame of the virtual screen to detect a change in the video frame. The method may continue with generating, by the server-side agent, an image of the change based on the detection. The method may further include sending, by the server-side agent, the image of the change to a client device. The virtual screen may be re-rendered on the client device based on the image of the change and the previous video frame.