Strollers with removable seats and related methods are disclosed herein. An example stroller includes a wheeled frame, a receiver coupled to the frame, and a seat. The seat includes a hub, a mount, and a lock disposed in the mount. The lock is to move from a first positon to a second position when the mount is disposed in the receiver to removably couple the seat to the frame. The seat includes a handle and a pin disposed between the handle and the hub. The handle is moveable from a retracted position to an extended position when the pin is in a third position relative to the handle and the lock is to move from the second position to the first position when the handle moves from the retracted position to the extended position.