Invention Grant
- Patent Title: Spirobicyclic analogues
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Application No.: US16769793Application Date: 2018-12-06
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Publication No.: US11059850B2Publication Date: 2021-07-13
- Inventor: Jonas Verhoeven , Guido Alfons F. Verniest , Johannes Wilhelmus John F. Thuring , Tongfei Wu , Vineet Pande , Lieven Meerpoel , Dirk Brehmer , Weimei Sun , Scott E. Denmark
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agency: BakerHostetler
- Priority: EP18163867 20180326
- International Application: PCT/EP2018/083808 WO 20181206
- International Announcement: WO2019/110734 WO 20190613
- Main IPC: C07H19/167
- IPC: C07H19/167
Abstract:
The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Public/Granted literature
- US20200369707A1 NOVEL SPIROBICYCLIC ANALOGUES Public/Granted day:2020-11-26
Information query
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