Invention Grant
- Patent Title: Biocidal peptide and preparation based thereon
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Application No.: US16483879Application Date: 2018-01-29
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Publication No.: US11059860B2Publication Date: 2021-07-13
- Inventor: Irina Vasil'evna Afonina , Alexandr Alexandrovich Kolobov , Nikolay Ivanovich Kolodkin , Mariya Pavlovna Smirnova , Ludmila Ivanovna Stefanenko
- Applicant: “VERTA RESEARCH-PRODUCTION COMPANY” LTD
- Applicant Address: RU St. Petersburg
- Assignee: “VERTA RESEARCH-PRODUCTION COMPANY” LTD
- Current Assignee: “VERTA RESEARCH-PRODUCTION COMPANY” LTD
- Current Assignee Address: RU St. Petersburg
- Agent Nadya Reingand; Yan Hankin
- Priority: RURU2017103887 20170206
- International Application: PCT/RU2018/000037 WO 20180129
- International Announcement: WO2018/143840 WO 20180809
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/00 ; A61K9/06 ; A61P31/04 ; A61P31/10 ; A61P31/12 ; A61P31/22 ; C07K7/08 ; C07K7/00

Abstract:
The invention discloses peptides having biocidal properties, more particularly antibacterial, antifungal, and antiviral properties, and preparations based thereon. A biocidal peptide of general formula Y-Ile-Leu-Pro-X-Lys-X-Pro-X-X-Pro-X-Arg-Arg-NH2, where X is 4-nitrophenylalanine; 4-chlorophenylalanine; 4-methoxyphenylalanine; D-phenylalanine; 4-aminophenylalanine; 4-aminobenzoylphenylalanine; homophenylalanine; 4-tertbutylphenylalanine; 2-methylphenylalanine; 4-fluorophenyl alanine; pentafluorophenylalanine; or 2-trifluoromethylphenylalanine; and Y is H or palmitoyl or aminoundecanoyl, and a preparation in the form of a gel with biocidal properties, containing, as an active substance, the peptide at a concentration of 0.001 to 0.1 wt %. The peptides demonstrate biocidal properties towards bacteria, including spore-forming bacteria, mold fungi, and viruses. The peptide-based gels can be used for treating bacterial and viral infectious diseases and infectious comorbidities.
Public/Granted literature
- US20200071358A1 BIOCIDAL PEPTIDE AND PREPARATION BASED THEREON Public/Granted day:2020-03-05
Information query
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