Invention Grant
- Patent Title: Chimeric antigen receptor (CAR) modulation
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Application No.: US16832751Application Date: 2020-03-27
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Publication No.: US11059864B2Publication Date: 2021-07-13
- Inventor: John Ngo , Wilson Wong , Meng Lai Nicole Wong , Huishan Li , Elliot P. Tague
- Applicant: TRUSTEES OF BOSTON UNIVERSITY
- Applicant Address: US MA Boston
- Assignee: TRUSTEES OF BOSTON UNIVERSITY
- Current Assignee: TRUSTEES OF BOSTON UNIVERSITY
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent Ronald I. Eisenstein; Nicole D. Kling
- Main IPC: C07K14/18
- IPC: C07K14/18 ; C07K14/81
Abstract:
The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
Public/Granted literature
- US20200308234A1 CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION Public/Granted day:2020-10-01
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