Invention Grant
- Patent Title: Self-assembly of protein-based biomaterials with multiple morphologies
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Application No.: US12618518Application Date: 2009-11-13
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Publication No.: US11059872B2Publication Date: 2021-07-13
- Inventor: Sarah E. Bondos , Alexandra M. Greer , Kathleen S. Matthews , Zhao Huang , Autumn Brawley , Jan Patterson
- Applicant: Sarah E. Bondos , Alexandra M. Greer , Kathleen S. Matthews , Zhao Huang , Autumn Brawley , Jan Patterson
- Applicant Address: US TX College Station; US TX Houston; US TX Houston; US TX Houston; US TX College Station; US TX College Station
- Assignee: Sarah E. Bondos,Alexandra M. Greer,Kathleen S. Matthews,Zhao Huang,Autumn Brawley,Jan Patterson
- Current Assignee: Sarah E. Bondos,Alexandra M. Greer,Kathleen S. Matthews,Zhao Huang,Autumn Brawley,Jan Patterson
- Current Assignee Address: US TX College Station; US TX Houston; US TX Houston; US TX Houston; US TX College Station; US TX College Station
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07K14/47
- IPC: C07K14/47

Abstract:
The present disclosure relates, in some embodiments, to a composition comprising a biomaterial. A biomaterial may comprise, for example, one or more molecules capable of self-association and/or self-assembly. In some embodiments, a biomaterial may comprise one or more polypeptides and/or proteins. A biomaterial may comprise, for example, two or more self-assembled Ultrabithorax (Ubx) protein molecules. A Ubx protein, in some embodiments, may be any wild type Drosophila melanogaster Ultrabithorax protein, including any natural or non-natural isoforms (e.g., alternative splicing isoforms). The present disclosure relates, in some embodiments, to a method of making a biomaterial comprising contacting two or more Ubx protein molecules under conditions that permit self-assembly to form a first fibril and contacting the first fibril to a second fibril.
Public/Granted literature
- US20100143436A1 SELF-ASSEMBLY OF PROTEIN-BASED BIOMATERIALS WITH MULTIPLE MORPHOLOGIES Public/Granted day:2010-06-10
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