Invention Grant
- Patent Title: Chimeric antigen receptor molecules and uses thereof
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Application No.: US15771128Application Date: 2016-10-27
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Publication No.: US11059879B2Publication Date: 2021-07-13
- Inventor: Radhika Thokala , Laurence J.N. Cooper , Simon Olivares
- Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- International Application: PCT/US2016/059010 WO 20161027
- International Announcement: WO2017/075147 WO 20170504
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61K39/44 ; A61K39/00 ; A61K39/395 ; A61P35/02 ; A61P35/00 ; C07K14/725 ; C07K16/28 ; A61K38/00
Abstract:
Chimeric antigen receptor (CAR) polypeptides are provided comprising an antigen binding domain; a hinge domain; a transmembrane domain and an intracellular signaling domain, wherein the CAR polypeptide binds to a target antigen and wherein the antigen binding domain comprises HCDR sequences from a first antibody that binds to the target antigen and LCDR sequences from a second antibody that binds to the target antigen. In certain aspects, the target antigen is CD123.
Public/Granted literature
- US20190055299A1 CHIMERIC ANTIGEN RECEPTOR MOLECULES AND USES THEREOF Public/Granted day:2019-02-21
Information query
