Invention Grant
- Patent Title: Chimeric antigen receptors targeting Fc receptor-like 5 and uses thereof
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Application No.: US15614108Application Date: 2017-06-05
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Publication No.: US11059891B2Publication Date: 2021-07-13
- Inventor: Renier J. Brentjens , Eric L. Smith , Cheng Liu
- Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER , EUREKA THERAPEUTICS, INC.
- Applicant Address: US NY New York; US CA Emeryville
- Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee Address: US NY New York; US CA Emeryville
- Agency: Baker Botts L.L.P.
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/28 ; A61K35/17 ; C07K14/725 ; C07K14/705 ; C12N9/12 ; A61K39/00 ; C07K16/30 ; C12N5/0783 ; C12N15/86
Abstract:
The presently disclosed subject matter provides for methods and compositions for treating a neoplasia (e.g., multiple myeloma). It relates to chimeric antigen receptors (CARs) that specifically target Fc Receptor-like 5 (FcRL5), e.g., domain 9 of FcRL5, and immunoresponsive cells comprising such CARs. The presently disclosed FcRL5-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.
Public/Granted literature
- US20170275362A1 CHIMERIC ANTIGEN RECEPTORS TARGETING FC RECEPTOR-LIKE 5 AND USES THEREOF Public/Granted day:2017-09-28
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