- Patent Title: Low-viscosity antigen binding proteins and methods of making them
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Application No.: US16338292Application Date: 2017-09-28
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Publication No.: US11059908B2Publication Date: 2021-07-13
- Inventor: Joon Hoi Huh , Riki Stevenson , Pavel Bondarenko , Andrew Nichols , Da Ren , Neeraj Jagdish Agrawal
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Timothy J. Gaul
- International Application: PCT/US2017/053967 WO 20170928
- International Announcement: WO2018/064307 WO 20180405
- Main IPC: C07K16/40
- IPC: C07K16/40 ; C07K16/28 ; G01N11/14
Abstract:
The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
Public/Granted literature
- US20190233543A1 LOW-VISCOSITY ANTIGEN BINDING PROTEINS AND METHODS OF MAKING THEM Public/Granted day:2019-08-01
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