Invention Grant
- Patent Title: Early vascular cell population
-
Application No.: US16000289Application Date: 2018-06-05
-
Publication No.: US11060064B2Publication Date: 2021-07-13
- Inventor: Sharon Gerecht , Sravanti Kusuma
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Venable LLP
- Agent Keith G. Haddaway; Miguel A. Lopez
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C12N5/071 ; A61K38/39 ; A61K31/00
Abstract:
The present invention relates to the area of in vitro cell populations useful for generating vascular networks in vitro and are suitable for use in vivo for regeneration of vascular tissue. In some embodiments, the bipotent cell population of the present invention comprise endothelial cells and pericytes that express vascular endothelial cadherin and are 95% or more positive for CD105 and CD146, and which work syergistically to recreate vascular tissues in vitro.
Public/Granted literature
- US20180298329A1 SELF-ORGANIZED VASCULAR NETWORKS FROM HUMAN PLURIPOTENT STEM CELLS IN A SYNTHETIC MATRIX Public/Granted day:2018-10-18
Information query
