Invention Grant
- Patent Title: Increased biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors in a recombinant host cell
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Application No.: US16324284Application Date: 2017-08-09
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Publication No.: US11060071B2Publication Date: 2021-07-13
- Inventor: Esben Halkjaer Hansen , Markus Schwab , Philipp Berninger , Fanny Delgrange , Franziska Grassinger
- Applicant: River Stone Biotech LLC
- Applicant Address: US MA Cambridge
- Assignee: River Stone Biotech LLC
- Current Assignee: River Stone Biotech LLC
- Current Assignee Address: US MA Cambridge
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/EP2017/070253 WO 20170809
- International Announcement: WO2018/029282 WO 20180215
- Main IPC: C12N9/04
- IPC: C12N9/04 ; C12N9/02 ; C12P17/12
Abstract:
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.
Public/Granted literature
- US20190338255A1 BIOSYNTHESIS OF BENZYLISOQUINOLINE ALKALOIDS AND BENZYLISOQUINOLINE ALKALOID PRECURSORS Public/Granted day:2019-11-07
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