Invention Grant
- Patent Title: Methods and compositions for producing double allele knock outs
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Application No.: US15599896Application Date: 2017-05-19
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Publication No.: US11060083B2Publication Date: 2021-07-13
- Inventor: Bo Yu , James Larrick
- Applicant: Larix Bioscience LLC
- Applicant Address: US CA Sunnyvale
- Assignee: Larix Bioscience LLC
- Current Assignee: Larix Bioscience LLC
- Current Assignee Address: US CA Sunnyvale
- Agency: HelixIP LLP
- Main IPC: C12N15/67
- IPC: C12N15/67 ; C12N15/79 ; C12N15/113 ; C12N15/10 ; C12N15/90
Abstract:
The present invention provides a method and compositions utilizing the CRISPR system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced ADCC activity.
Public/Granted literature
- US20210108190A9 METHODS AND COMPOSITIONS FOR PRODUCING DOUBLE ALLELE KNOCK OUTS Public/Granted day:2021-04-15
Information query
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