A touch operation response method and device in the field of human-computer interaction. The method includes: determining a first operation area and a second operation area in the touch display screen; receiving a first touch operation and a second touch operation acting on the touch display screen within a preset time period; determining an operation area on which the first touch operation acts, where the touch display screen includes the first operation area and the second operation area; determining an operation area on which the second touch operation acts; based on the operation area on which the first touch operation acts and the operation area on which the second touch operation acts, determining whether to respond to the first touch operation and/or the second touch operation.