The present invention provides a computer implemented method for generating translatable and accessible multimedia presentations. The method can include transforming a presentation master file defining a multimedia presentation into each of a text file and a variables file, generating a plurality of slides for a slide show with text strings from the text file and imagery and audiovisual elements from the variables file, and launching the slide show. Transforming a presentation master file into each of a text file and a variables file can include additionally transforming the presentation master file into a visual markup language document emulating the multimedia presentation. As such, in an aspect of the embodiment, the method further can include detecting an assistive technology, and rendering the visual markup language document in lieu of the slide show.