Invention Grant
- Patent Title: Inhibitors of DUX4 induction for regulation of muscle function
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Application No.: US16753247Application Date: 2018-10-26
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Publication No.: US11065243B2Publication Date: 2021-07-20
- Inventor: Amanda Rickard , Uli Schmidt , Alexander Kiselyov
- Applicant: Sonic Master Limited
- Applicant Address: VG Tortola
- Assignee: Sonic Master Limited
- Current Assignee: Sonic Master Limited
- Current Assignee Address: VG Tortola
- Agency: Gable Gotwals
- International Application: PCT/US2018/057856 WO 20181026
- International Announcement: WO2019/084499 WO 20190502
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; A61K31/519 ; A61K9/00 ; A61P21/00
Abstract:
Disclosed are methods and compositions for the treatment of facioscapulohumeral muscular dystrophy. In some cases, the methods and compositions involve the use of kinase inhibitors include Src, Syk, Abl, Tie, Flt, ErbB, Trk, PRKDC, and Yes families to repress DUX4 expression in muscle cells. Further disclosed are methods and cell based assays for screening compounds for the treatment of facioscapulohumeral muscular dystrophy.
Public/Granted literature
- US20200330452A1 Inhibitors of Dux4 Induction for Regulation of Muscle Function Public/Granted day:2020-10-22
Information query
IPC分类:
