The disclosed systems, structures, and methods are directed to a multi-level multi-mode transmitter, employing a first pre-driver configured to receive M-parallel data streams and to convert the M-parallel data streams into a serial data stream, a first voltage-driver configured to operate on the single data stream and to provide a voltage in accordance with the single data stream, a second pre-driver configured to receive and process the M-parallel data streams in accordance with at least one of the following modes: moderate impedance (Z) post-cursor mode, moderate Z pre-cursor mode, low Z high-swing mode, low Z post-cursor mode, and low Z pre-cursor mode, and convert the processed M-parallel data streams into a first serial stream and a second serial stream and a second voltage-driver configured to operate on the first serial stream and the second serial stream and to provide a voltage.