A vasculature simulation device includes an aortic conduit having an inner bore corresponding to a human aorta, a first femoral conduit and a second femoral conduit having an inner bore of a diameter corresponding to a human femoral artery and disposed in fluid communication with the second end of the aortic conduit, and a return conduit in fluid receiving communication with the second end of the aortic conduit. A fluid pump is in fluid receiving communication with the return conduit and is also in fluid providing communication with the first end of the aortic conduit. An access site formed of a penetrable material is disposed adjacent to the first femoral conduit.