Invention Grant
- Patent Title: Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising ibuprofen
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Application No.: US17008108Application Date: 2020-08-31
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Publication No.: US11077067B2Publication Date: 2021-08-03
- Inventor: Rosaleen McLaughlin , Simon Andrew Martyn Howes , Craig Wheadon , Jonathon Whitehouse , Adam Parker
- Applicant: Catalent U.K. Swindon Zydis Limited
- Applicant Address: GB Swindon
- Assignee: Catalent U.K. Swindon Zydis Limited
- Current Assignee: Catalent U.K. Swindon Zydis Limited
- Current Assignee Address: GB Swindon
- Agency: Morrison & Foerster LLP
- Main IPC: A61K9/50
- IPC: A61K9/50 ; A61K47/44 ; A61K9/19 ; A61K31/192 ; A61K47/26 ; A61K47/36 ; A61K47/42

Abstract:
Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions comprising Ibuprofen using solventless mixing methods. Excess coating material that is not bound to coated Ibuprofen may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Additionally, the compositions can be formulated to preserve the functional coating of coated Ibuprofen and to minimize aeration of Ibuprofen when mixed into suspension.
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