Invention Grant
- Patent Title: Non-bioconvertible C3-substituted pregnenolone derivatives for use in the treatment of substance use disorders
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Application No.: US15773798Application Date: 2016-11-04
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Publication No.: US11077122B2Publication Date: 2021-08-03
- Inventor: George F. Koob , Barbara Jean Mason , Olivier George , Etienne Baulieu , Isabelle Villey
- Applicant: MAPREG
- Applicant Address: FR Le Kremlin Bicetre
- Assignee: MAPREG
- Current Assignee: MAPREG
- Current Assignee Address: FR Le Kremlin Bicetre
- Agency: Arrigo, Lee, Guttman & Mouta-Bellum LLP
- Priority: EP15306765 20151106
- International Application: PCT/EP2016/076741 WO 20161104
- International Announcement: WO2017/077082 WO 20170511
- Main IPC: A61K31/57
- IPC: A61K31/57 ; A61P25/32
Abstract:
The present invention relates to the use of non-bioconvertible C3-substituted pregnenolone derivatives of formula (I), with no significant affinity for hormonal receptors or receptors of the central nervous system, in the treatment of substance use disorders, and in particular of alcohol use disorder.
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