Invention Grant
- Patent Title: Methods for reducing HIV-1 mother-to-child transmission by inducing V3-specific or CD4 binding site-specific antibodies
-
Application No.: US15025031Application Date: 2014-09-26
-
Publication No.: US11077130B2Publication Date: 2021-08-03
- Inventor: Barton F. Haynes , Sallie Permar , M. Anthony Moody , Feng Gao , Hua-Xin Liao , Georgia Tomaras , David C. Montefiori
- Applicant: DUKE UNIVERSITY
- Applicant Address: US NC Durham
- Assignee: DUKE UNIVERSITY
- Current Assignee: DUKE UNIVERSITY
- Current Assignee Address: US NC Durham
- Agency: Baker Donelson
- International Application: PCT/US2014/057809 WO 20140926
- International Announcement: WO2015/048512 WO 20150402
- Main IPC: A61K39/21
- IPC: A61K39/21 ; A61K31/7088 ; G01N33/569 ; A61K39/395 ; C07K14/16 ; C07K14/005
Abstract:
The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
Public/Granted literature
- US20160339051A1 HIV-1 MOTHER-TO-CHILD TRANSMISSION CORRELATES OF PROTECTION AND VACCINE Public/Granted day:2016-11-24
Information query
