Invention Grant
- Patent Title: Methods for inducing selective apoptosis
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Application No.: US15886309Application Date: 2018-02-01
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Publication No.: US11077176B2Publication Date: 2021-08-03
- Inventor: Malcolm K. Brenner
- Applicant: Baylor College of Medicine
- Applicant Address: US TX Houston
- Assignee: Baylor College of Medicine
- Current Assignee: Baylor College of Medicine
- Current Assignee Address: US TX Houston
- Agency: Jones Day
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61K38/52 ; A61K35/28 ; A61K35/545 ; A61K39/00 ; C12N5/0783 ; C12N5/0775 ; A61K38/48

Abstract:
Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by modifying T cells before administration to a patient, so that they may be selectively killed if GvHD develops in the patient.
Public/Granted literature
- US20180243385A1 METHODS FOR INDUCING SELECTIVE APOPTOSIS Public/Granted day:2018-08-30
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