Invention Grant
- Patent Title: Chimeric antigen receptor (CAR) that targets chemokine receptor CCR4 and its use
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Application No.: US16334724Application Date: 2017-09-20
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Publication No.: US11077178B2Publication Date: 2021-08-03
- Inventor: Liyanage Parakrama Perera , Thomas Alexander Waldmann , Kevin Charles Conlon , Pin-Yu Perera
- Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services , The United States Government as represented by the Department of Veterans Affairs
- Applicant Address: US MD Bethesda; US DC Washington
- Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services,The United States Government as represented by the Department of Veterans Affairs
- Current Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services,The United States Government as represented by the Department of Veterans Affairs
- Current Assignee Address: US MD Bethesda; US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2017/052437 WO 20170920
- International Announcement: WO2018/057585 WO 20180329
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61P35/02 ; C07K14/725 ; C07K14/705 ; C07K16/28 ; A61P35/00 ; A61K31/7076 ; A61K35/17 ; A61K31/675
Abstract:
A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.
Public/Granted literature
- US20190233526A1 CHIMERIC ANTIGEN RECEPTOR (CAR) THAT TARGETS CHEMOKINE RECEPTOR CCR4 AND ITS USE Public/Granted day:2019-08-01
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