Invention Grant
- Patent Title: Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction
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Application No.: US16422588Application Date: 2019-05-24
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Publication No.: US11077304B2Publication Date: 2021-08-03
- Inventor: Bruce H. KenKnight , Jeffrey L. Ardell , Imad Libbus , Badri Amurthur
- Applicant: LivaNova USA, Inc. , EAST TENNESSEE STATE UNIVERSITY
- Applicant Address: US TX Houston; US TN Johnson City
- Assignee: LivaNova USA, Inc.,EAST TENNESSEE STATE UNIVERSITY
- Current Assignee: LivaNova USA, Inc.,EAST TENNESSEE STATE UNIVERSITY
- Current Assignee Address: US TX Houston; US TN Johnson City
- Agency: Foley & Lardner LLP
- Main IPC: A61N1/36
- IPC: A61N1/36

Abstract:
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
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