Invention Grant
- Patent Title: Triazole conjugated ureas, thioureas, carbamates, and reversed carbamates for PSMA-targeted imaging agents and uses thereof
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Application No.: US15752340Application Date: 2016-08-15
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Publication No.: US11078166B2Publication Date: 2021-08-03
- Inventor: Martin G. Pomper , Ying Chen , Xing Yang , Ronnie C. Mease , Sangeeta Ray
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Casimir Jones, S.C.
- Agent Jeffrey W. Childers
- International Application: PCT/US2016/046981 WO 20160815
- International Announcement: WO2017/027870 WO 20170216
- Main IPC: C07D249/04
- IPC: C07D249/04 ; A61K51/04 ; C07B59/00
Abstract:
Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.
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