Invention Grant
- Patent Title: Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
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Application No.: US16315307Application Date: 2017-07-04
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Publication No.: US11078192B2Publication Date: 2021-08-03
- Inventor: Yuguang Wang , Zusheng Xu , Tianzhi Wu , Min He , Nong Zhang
- Applicant: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
- Applicant Address: CN Guangzhou
- Assignee: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
- Current Assignee: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
- Current Assignee Address: CN Guangzhou
- Agency: Dilworth IP, LLC
- Priority: CN201610523836.9 20160705
- International Application: PCT/CN2017/091643 WO 20170704
- International Announcement: WO2018/006795 WO 20180111
- Main IPC: C07D405/10
- IPC: C07D405/10 ; C07D405/04 ; C07D207/08 ; C07D211/60 ; C07D213/38 ; C07D213/48 ; C07D231/10 ; C07D231/12 ; C07D319/18 ; A61P35/00 ; C07C22/04 ; C07C22/08 ; C07C25/24 ; C07C43/225 ; C07C47/548 ; C07C47/55 ; C07C47/575 ; C07C69/94 ; C07C215/10 ; C07C217/58 ; C07C229/22 ; C07C229/24 ; C07C229/64 ; C07C233/18 ; C07C235/84 ; C07C237/30 ; C07C255/56
Abstract:
Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory effect on PD-1 and PD-L1, and can effectively relieve or treat cancers and other related diseases.
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