Invention Grant
- Patent Title: AAVrh.10 variants with host antibody escape capabilities and altered tissue targeting properties
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Application No.: US16338397Application Date: 2017-09-29
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Publication No.: US11078238B2Publication Date: 2021-08-03
- Inventor: Mavis Agbandje-McKenna , Mario Mietzsch
- Applicant: University of Florida Research Foundation, Incorporated
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation, Incorporated
- Current Assignee: University of Florida Research Foundation, Incorporated
- Current Assignee Address: US FL Gainesville
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2017/054600 WO 20170929
- International Announcement: WO2018/064624 WO 20180405
- Main IPC: C12N7/00
- IPC: C12N7/00 ; C12N15/00 ; C07K14/005 ; C12N15/86 ; C12N15/85
Abstract:
This disclosure relates to variant AAVrh.10 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles.
Information query
