Invention Grant
- Patent Title: Prefusion PIV F immunogens and their use
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Application No.: US16344772Application Date: 2017-10-25
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Publication No.: US11078239B2Publication Date: 2021-08-03
- Inventor: Baoshan Zhang , Guillaume Stewart-Jones , Tongqing Zhou , John Mascola , Kai Xu , Yongping Yang , Paul Thomas , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
- Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services , Institute for Research in Biomedicine
- Applicant Address: US MD Bethesda; CH Bellinzona
- Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services,Institute for Research in Biomedicine
- Current Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services,Institute for Research in Biomedicine
- Current Assignee Address: US MD Bethesda; CH Bellinzona
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2017/058322 WO 20171025
- International Announcement: WO2018/081289 WO 20180503
- Main IPC: A61K39/155
- IPC: A61K39/155 ; C07K14/005 ; A61P31/14 ; C12N7/00
Abstract:
Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
Public/Granted literature
- US20200048311A1 PREFUSION PIV F IMMUNOGENS AND THEIR USE Public/Granted day:2020-02-13
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