Invention Grant
- Patent Title: Methods of treating and preventing Staphylococcus aureus infections and associated conditions
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Application No.: US16860716Application Date: 2020-04-28
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Publication No.: US11078258B2Publication Date: 2021-08-03
- Inventor: Victor J. Torres , Francis Alonzo, III
- Applicant: New York University
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: Troutman Pepper Hamilton Sanders LLP (Rochester)
- Main IPC: A61K39/085
- IPC: A61K39/085 ; C07K16/12 ; G01N33/50 ; G01N33/569 ; A61K39/40 ; A61K31/7088 ; A61K31/724 ; A61K38/16 ; A61K39/00
Abstract:
The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
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