Invention Grant
- Patent Title: Lysine decarboxylases having modifications at titratable amino acids
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Application No.: US16473215Application Date: 2016-12-30
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Publication No.: US11078473B2Publication Date: 2021-08-03
- Inventor: Howard Chou , Ling Chen , Wenqiang Lu , Xiucai Liu
- Applicant: CATHAY BIOTECH INC. , CIBT AMERICA INC.
- Applicant Address: CN Shanghai; US DE Newark
- Assignee: CATHAY BIOTECH INC.,CIBT AMERICA INC.
- Current Assignee: CATHAY BIOTECH INC.,CIBT AMERICA INC.
- Current Assignee Address: CN Shanghai; US DE Newark
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- International Application: PCT/CN2016/113516 WO 20161230
- International Announcement: WO2018/120025 WO 20180705
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C12P13/00
Abstract:
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganisms.
Public/Granted literature
- US20190330614A1 Lysine Decarboxylases having modifications At Titratable Amino Acids Public/Granted day:2019-10-31
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