Invention Grant
- Patent Title: Vector for targeting the human Rosa26 gene
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Application No.: US16664291Application Date: 2019-10-25
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Publication No.: US11078494B2Publication Date: 2021-08-03
- Inventor: Gordon Keller , Stefan Irion , Herve Luche , Paul Gadue , Hans J. Fehling
- Applicant: Icahn School of Medicine at Mount Sinai
- Applicant Address: US NY New York
- Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee Address: US NY New York
- Agency: Fox Rothschild LLP
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/85 ; C12N5/0735 ; C07K14/47 ; C12N15/90
Abstract:
The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
Public/Granted literature
- US20200071719A1 STEM CELL GENE TARGETING Public/Granted day:2020-03-05
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