Invention Grant
- Patent Title: Method for evaluating blood coagulation reaction
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Application No.: US14431425Application Date: 2013-09-26
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Publication No.: US11078518B2Publication Date: 2021-08-03
- Inventor: Tetsuhiro Soeda , Takehisa Kitazawa , Midori Shima
- Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA , PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
- Applicant Address: JP Tokyo; JP Nara
- Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA,PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
- Current Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA,PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
- Current Assignee Address: JP Tokyo; JP Nara
- Agency: Nixon & Vanderhye, P.C.
- Priority: JPJP2012-217925 20120928
- International Application: PCT/JP2013/075978 WO 20130926
- International Announcement: WO2014/050926 WO 20140403
- Main IPC: C12Q1/56
- IPC: C12Q1/56 ; G01N33/86 ; C12N9/64
Abstract:
Various methods for evaluating hemostatic effect and various blood coagulation initiation reagents were studied to construct a method for evaluating blood coagulation reaction mediated by a substance having an activity of substituting for coagulation factor VIII (FVIII). As a result, it was discovered that by using a coagulation initiation reagent containing activated coagulation factor XI (FXIa) and phospholipids, the effect of a substance having an activity of substituting for coagulation factor VIII (FVIII) on blood coagulation reaction can be evaluated using the amount of thrombin generated in the blood sample as an indicator.
Public/Granted literature
- US20150240287A1 METHOD FOR EVALUATING BLOOD COAGULATION REACTION Public/Granted day:2015-08-27
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