Invention Grant
- Patent Title: Methods for determining differences in alpha-4 integrin activity by correlating differences in sVCAM and/or sMAdCAM levels
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Application No.: US15131804Application Date: 2016-04-18
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Publication No.: US11079393B2Publication Date: 2021-08-03
- Inventor: Alissa A. Chackerian
- Applicant: BIOGEN MA INC.
- Applicant Address: US MA Cambridge
- Assignee: BIOGEN MA INC.
- Current Assignee: BIOGEN MA INC.
- Current Assignee Address: US MA Cambridge
- Agent Todd A. Lonenz
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N33/566 ; C07K16/28 ; A61K39/00
Abstract:
Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (sVCAM) and/or soluble mucosal addressin cell adhesion molecule (sMAdCAM) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (PK/PD) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation.
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