Described herein are systems and methods for transforming clinical guideline documents into computer interpretable guidelines (“CIGs”). One embodiment refers to a method comprising prompting a user, via a graphical user interface (“GUI”), for a plurality of clinical guideline entry steps, receiving, via the GUI, clinical guideline data, prompting the user, via the GUI, for a plurality of formal expression entry steps related to the clinical guideline data, receiving, via the GUI, a formal representation of the clinical guideline data and mapping the formal representation of the clinical data to a CIG.