A liquid discharge apparatus includes a liquid storing portion, a liquid discharge unit that discharges the liquid to a medium and performs printing, a supply flow path that communicates the liquid storing portion and the liquid discharge unit, an opening/closing mechanism including an opening/closing unit that brings the supply flow path into an open state or a closed state and an operation unit that operates the opening/closing unit, and a moving unit configured to move between a first position that is a normal position when performing the printing and a second position different from the first position. A range where the operation unit brings supply flow path into a transient state between the open state and the closed state includes a position of the operation unit at which the operation unit interferes with the moving unit located in the first position.