Invention Grant
- Patent Title: Process for preparing beta 3 agonists and intermediates
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Application No.: US16914138Application Date: 2020-06-26
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Publication No.: US11091493B2Publication Date: 2021-08-17
- Inventor: Feng Xu , Zhuqing Liu , Richard Desmond , Jeonghan Park , Alexei Kalinin , Birgit Kosjek , Hallena Strotman , Hongmei Li , Johannah Moncecchi
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D207/08 ; C07C215/30 ; C07D207/12 ; C12P17/10
Abstract:
The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KED) biocatalyst enzymes and methods of using the biocatalysts.
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