- Patent Title: Anti-chondroitin sulfate proteoglycan 4 antibodies and uses thereof
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Application No.: US15526309Application Date: 2015-11-12
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Publication No.: US11091547B2Publication Date: 2021-08-17
- Inventor: Soldano Ferrone , Nai-Kong V. Cheung , Ming Cheng
- Applicant: Memorial Sloan Kettering Cancer Center , The General Hospital Corporation
- Applicant Address: US NY New York; US MA Boston
- Assignee: Memorial Sloan Kettering Cancer Center,The General Hospital Corporation
- Current Assignee: Memorial Sloan Kettering Cancer Center,The General Hospital Corporation
- Current Assignee Address: US NY New York; US MA Boston
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Tracy L. Vrablik
- International Application: PCT/US2015/060465 WO 20151112
- International Announcement: WO2016/077638 WO 20160519
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07H21/04 ; C12N5/12 ; C07K16/28 ; C07K16/30 ; C07K16/44 ; A61K39/00
Abstract:
Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.
Public/Granted literature
- US20170342151A1 ANTI-CHONDROITIN SULFATE PROTEOGLYCAN 4 ANTIBODIES AND USES THEREOF Public/Granted day:2017-11-30
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