- Patent Title: Composition for inducing dedifferentiation into cancer stem cells comprising ribosome-activating inhibitor as active ingredient, cancer organoid culture method and anticancer drug screening platform based thereon
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Application No.: US16105978Application Date: 2018-08-21
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Publication No.: US11091740B2Publication Date: 2021-08-17
- Inventor: Yuseok Moon , Seung Joon Lee
- Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
- Applicant Address: KR Busan
- Assignee: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
- Current Assignee: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
- Current Assignee Address: KR Busan
- Agency: Revolution IP, PLLC
- Priority: KR10-2016-0026311 20160304
- Main IPC: G01N33/50
- IPC: G01N33/50 ; C12N5/095
Abstract:
A composition for inducing dedifferentiation from cancer cells to cancer stem cells comprising a ribosome-activating inhibitor as an active ingredient, a method of culturing a cancer organoid based thereon and an anticancer drug screening platform, and the increase of colorectal cancer stem cell group induced by the exposure of ribosome-inactivating stress was regulated by the ATF3 gene.
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