A control system of an internal combustion engine comprises an air-fuel ratio sensor 40, 41 detecting an air-fuel ratio of exhaust gas, a current detecting device 61 detecting an output current of the air-fuel ratio sensor, a voltage applying device 60 applying voltage to the air-fuel ratio sensor, and a voltage control part 81 configured to control voltage applied to the air-fuel ratio sensor through the voltage applying device. The voltage control part is configured to set the applied voltage to a reference voltage determined so that the output current becomes zero when an air-fuel ratio of inflowing exhaust gas flowing into the air-fuel ratio sensor is a stoichiometric air-fuel ratio, and correct the reference voltage so that the output current detected by the current detecting device becomes zero when it is judged that the air-fuel ratio of the inflowing exhaust gas is the stoichiometric air-fuel ratio.