A method and apparatus are disclosed herein for automatically creating a comparison layout using series matching based on image similarity. In one embodiment, a method for displaying series images in a graphical user interface (GUI) comprises receiving a current study and one or more previously-created studies, each of the current study and the one or more previously-created studies having at least one images series; performing, using one or more processors performing an image recognition routine, a comparison between at least one image series in the current study and at least one image series in each of the one or more previously-created studies by calculating image similarity between the at least one image series in the current study and the at least one image series of said each of the one or more previously-created studies; and creating a comparison layout in the GUI with at least one image from one image series of the current study adjacent to at least one image from an image series of at least one of the one or more previously-created studies.