A phase-locked loop (PLL) and a method for calibrating a VCO therein are provided. The PLL comprises a frequency-phase detector, a charge pump, a loop filter, a VCO, a divider and a calibration circuit. The calibration circuit is used to acquire a frequency of an output signal of the VCO, to calibrate the frequency of the output signal according to an expected frequency, and to acquire frequency control parameters of the VCO at the current signal frequency. The amplitude and gain of the output signal are kept constant according to the amplitude control parameters and gain control parameters. The PLL can meet the demands on frequencies of multiple protocols and can adaptively look up and stabilize the suitable frequency. It solves the issue that the amplitude of the output signal of the VCO is not constant when the PLL operates in a large frequency range.